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Yitzhak Zimmer Selected Research

5- ((2,6- dichlorobenzyl)sulfonyl)- 3- ((3,5- dimethyl- 4- ((2- (pyrrolidin- 1- ylmethyl)pyrrolidin- 1- yl)carbonyl)- 1H- pyrrol- 2- yl)methylene)- 1,3- dihydro- 2H- indol- 2- one

2/2013Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells.
2/2012MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks.
10/2010MET Inhibition Results in DNA Breaks and Synergistically Sensitizes Tumor Cells to DNA-Damaging Agents Potentially by Breaching a Damage-Induced Checkpoint Arrest.

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Yitzhak Zimmer Research Topics

Disease

30Neoplasms (Cancer)
12/2023 - 11/2003
5Squamous Cell Carcinoma of Head and Neck
12/2022 - 01/2009
5Neoplasm Metastasis (Metastasis)
11/2020 - 11/2003
4Oncogene Addiction
03/2023 - 01/2019
3Genomic Instability
06/2023 - 01/2020
3Hypoxia (Hypoxemia)
11/2020 - 05/2015
2Hepatocellular Carcinoma (Hepatoma)
10/2019 - 07/2015
2Head and Neck Neoplasms (Head and Neck Cancer)
09/2014 - 03/2010
1Hematologic Neoplasms (Hematological Malignancy)
12/2023
1Lymphoma (Lymphomas)
12/2023
1Leukemia
12/2023
1Hepatitis
01/2021
1Ischemia
01/2021
1Reperfusion Injury
01/2021
1Prostatic Neoplasms (Prostate Cancer)
11/2020
1Mitochondrial Diseases (Mitochondrial Disease)
01/2019
1Lymphatic Metastasis
12/2018
1Stomach Neoplasms (Stomach Cancer)
11/2016
1Liver Neoplasms (Liver Cancer)
07/2015
1Adenocarcinoma
02/2013
1Carcinogenesis
02/2013
1Extranodal Extension
03/2010
1Glioblastoma (Glioblastoma Multiforme)
06/2008
1Squamous Cell Neoplasms (Squamous Cell Cancer)
11/2003

Drug/Important Bio-Agent (IBA)

13Proto-Oncogene Proteins c-metIBA
01/2020 - 11/2003
8Proteins (Proteins, Gene)FDA Link
12/2022 - 10/2009
7Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2017 - 07/2008
6DNA (Deoxyribonucleic Acid)IBA
12/2022 - 10/2010
5Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2020 - 09/2014
3Growth Factor ReceptorsIBA
06/2023 - 12/2013
3Biomarkers (Surrogate Marker)IBA
12/2022 - 09/2014
3Phosphotransferases (Kinase)IBA
12/2022 - 12/2013
3Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
01/2018 - 11/2003
3EMD1214063IBA
08/2015 - 02/2013
35- ((2,6- dichlorobenzyl)sulfonyl)- 3- ((3,5- dimethyl- 4- ((2- (pyrrolidin- 1- ylmethyl)pyrrolidin- 1- yl)carbonyl)- 1H- pyrrol- 2- yl)methylene)- 1,3- dihydro- 2H- indol- 2- oneIBA
02/2013 - 10/2010
2Messenger RNA (mRNA)IBA
12/2022 - 11/2016
2Oncogene Proteins (Oncogene Protein)IBA
12/2022 - 01/2019
2ras ProteinsIBA
01/2019 - 08/2015
1Interleukin-22 (IL-22)IBA
01/2021
1Concanavalin AIBA
01/2021
1CBLB502IBA
01/2021
1ElementsIBA
11/2020
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
11/2020
1HoloenzymesIBA
11/2020
1Verteporfin (Visudyne)FDA Link
10/2019
1Sorafenib (BAY 43-9006)FDA Link
10/2019
1tepotinibIBA
01/2019
1Codon (Codons)IBA
01/2019
1Amino AcidsFDA Link
01/2018
1Tyrosine Kinase InhibitorsIBA
01/2018
1Mitogen-Activated Protein KinasesIBA
01/2018
1LipidsIBA
01/2018
1Forkhead Box Protein M1IBA
11/2016
1A-Form DNA (A-DNA)IBA
11/2016
1Oxygen (Dioxygen)IBA
05/2015
1LigandsIBA
05/2015
1tyrosine receptor (receptor, tyrosine)IBA
05/2015
1Tyrosine (L-Tyrosine)FDA Link
12/2013
1Green Fluorescent ProteinsIBA
02/2012
1Doxorubicin (Adriamycin)FDA LinkGeneric
10/2010
1Protein Kinases (Protein Kinase)IBA
03/2010
1Capsules (Microcapsules)IBA
03/2010
1ErbB Receptors (EGF Receptor)IBA
06/2008

Therapy/Procedure

11Therapeutics
12/2023 - 06/2008
8Radiotherapy
12/2023 - 11/2003
2Drug Therapy (Chemotherapy)
02/2013 - 01/2009
1Immunotherapy
12/2023
1Neck Dissection (Radical Neck Dissection)
03/2010
1Chemoradiotherapy
06/2008